CURRICULUM VITAE
  • Name : AZIMAHTOL HAWARIAH BT. LOPE PIHIE
  • Qualifications :
     

    Ijazah

    Bidang

    Tahun

    Instituisi

     

    BSc. (Honours)

    2nd Upper

     

    Biologi

     

    1976

     

    Universiti Kebangsaan

    Malaysia, MALAYSIA

     

     

    MSc.

     

     

     

    Biokimia Pembiakan

          

    1978

     

    University of Strathclyde,

    Glasgow, UK

     

    PhD

     

    Biokimia Klinik

     

    1985

     

    University of Glasgow,

    Scotland, UK

     
  • Specialisation :

    Clinical Biochemistry

    Clinical Endocrinology

    Cancer Cell Biology

    Medicinal Plants

     
  • Areas of Research :
     

    1.      Development of SPD as anticancer drug

    2.      Evaluation of therapeutic and Toxic potential of natural product

    3.      Semiscale production of SPD through bioreactor propagation for Clinical trial

    4.      Pharmacological and Toxicological Evaluation of Extracts from Centella asiatica and Eurycoma longifolia Jack.

    5.      Identification of goniothalamin-targeted proteins and goniothalamin-induced proteins

    6.      Antiviral activity of selected Malaysia medicinal plants

    7.      Development of immunological-based thymidine kinase (TK) assay system as a tumor marker

    8.      Further studies of styrylpyrone derivative (SPD)

    9.      Development of cosmeceutical and phytopharmaceutical products from Curcuma xanthorriza (Temu Lawak) and Zingiber Zerumbet (Lempoyang).

    10.  Pharmacological and toxicological evaluation of new isolated bioactive compounds from Hydnophytum formicarium Jack (Rubiaceae)

  • Current Projects and Grants :

    1. Development of Cosmeceuticals and Pharmaceuticals from Zingiber zerumbet Smith and Curcuma xanthorrhiza. [06-02-02-001 BTK/ER/015(3a)]

    2.  Further studies of styrylpyrone derivative (SPD). [06-02-02-0013/PR000207-04]

    3.  Development of an immunological based assay system for tyhmidine kinase as a tumor marker. [06-02-02-0012/PR0002-07-03]

    4. Anticancer  and aphrodisiac properties of Eurycoma longifolia Jack [33-00-90-173]

     
  • Selected Publications :
    • Rafidah Husen, Azimahtol Hawariah L.P. & Meenakshii Nallappan. 2004. Screening for antihyperglycaemic activity in several local herbs of Malaysia. Journal of Ethnopharmacology 95: 205–208
    • Lee, T.C.A., Azimahtol, H.L.P. & Tan, A.N. 2003. Styrylpyrone Derivative (SPD) Induces Apoptosis in a Caspase-7-dependent Manner in the Human Breast Cancer Cell Line MCF-7. Cancer Cell International Vol 3: 16.
    •  Alvin Lee, T.C. & Azimahtol Hawariah, L.P. 2003. Styrylpyrone Derivative (SPD) Induces Apoptosis through the Up-regulation of Bax in the Human Breast Cancer Cell Line MCF-7. Journal of Biochemistry and Molecular Biology. Vol 36(3): 269-274.
    • Meenakshii, N., Lee, A., Azimahtol Hawariah, L. P. and Hasidah, S. 2000. Increase levels of apoptosis correlate with p53 protein accumulation in response to styrylpyrone derivative (SPD) treatment of the “Huggins tumor”. Journal of Malaysian Applied Biology, Vol. 29(1&2): 121-126
    • Meenakshi, N., Teoh, P. L., Azimahtol Hawariah, L. P. and Hasidah, M. S. Styrylpyrone Derivative (SPD) induced apoptosis in ovarian cancer cells correlates with down-regulation of BCL-2 and MAPK but up-regulation of BAX without alteration of p53 and c-JUN protein level. Journal Tropical Medicinal Plant, Vol.1(Dec 2000): 1-5.
    • Seri Chempaka M. Y., Azimahtol Hawariah L. P., Halimah A. S. and Hasidah. M. S. 2000. An antitumor-Stylrylpyrone Derivative (SPD) lowers serum cholesterol levels and atherosclerotic lesions in hypercholesterolemic rats, Malaysian Applied Biology, 28(1 &2), 131-136.
    • Teoh, P. L. and Azimahtol Hawariah L. P. 2000. Effects of goniothalamin of bcl-2 and bax genes in human ovarian carcinoma cell line, CaOV-3, Malaysian Applied Biology, 28(1 &2), 113-118.
    • Azimahtol Hawariah L. P., Stanslas, J. and Laily, D. 1998. Non-steroid receptor mediated antiproliferative activity of Styrylpyrone Derivative (SPD) in human breast cancer cell lines. Anticancer Research, 18(2): 1739-1744.
    • Azimahtol Hawariah L. P. and Stanlas J. 1998. Antagonistic effects of Styrylpyrone Derivative (SPD) on 7, 12, dimethylbenzanthracene-induced rat mammary tumors. In vivo, 12(4): 403-410.
    • Azimahtol Hawariah L. P. and Stanlas J. 1998. In vitro response of human breast cancer cell lines to the growth-inhibitory effects of Styrylpyrone Derivative (SPD) and assesment of its antiestrogenicity. Anticancer research, 18(6): 4383-4386.

    Books

    ·        Azimahtol Hawariah L. P. 1999. A Gift of Biodiversity; Some Anticancer Drugs Developed From Natural Product. In. Traditional and Alternative Medicine in Contemporary Healthcare. Institute Medical Research/WHO Kuala Lumpur . 27-30.

    ·        Azimahtol Hawariah, L.P. 1998: Understanding Cancer, Universiti Kebangsaan Malaysia Publisher, Bangi, Malaysia (ISBN 967-94240-4-9) pp 164.

    ·        Azimahtol Hawariah, L.P. 1998: Hormon and Cancer, Universiti Putra Malaysia Publisher. (ISBN 983-9319-33-7) pp 56.

    ·        Azimahtol Hawariah, L.P. 1998: Prostate Cancer, Universiti Putra Malaysia Publisher. (ISBN 983- 9319-36-1) pp 57.

    ·        Azimahtol Hawariah, L.P. 1998: Breast Cancer, Universiti Putra Malaysia Publisher. (ISBN 983- 9319-34-5) pp 76.

    ·        Azimahtol Hawariah, L.P. 1998: Ovarian Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-37-X) pp 60.

    ·        Azimahtol Hawariah, L.P. 1998: Uterus Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-35-3) pp 56.

    ·        Azimahtol Hawariah, L.P. 1998: Cervical Cancer, Universiti Putra Malaysia Publisher, (ISBN 983- 9319-38-8) pp 49.

    ·        Che Jah Mohammad & Azimahtol Hawariah, L.P. 1998: Basic Biology and Biochemistry 1 Universiti Kebangsaan Malaysia Publisher. (ISBN 983-93192-8-0) pp 158.

     
  • Contact Information :
    - Address
      SCHOOL OF BIOSCIENCES & BIOTECHNOLOGY
      FACULTY OF SCIENCE & TECHNOLOGY
      Universiti Kebangsaan Malaysia
      43600 UKM Bangi
      Selangor
      Malaysia
    - Phone Number
      603-89213813
    - Fax Number
      603-89252698
    - E-mail