BSc Biotechnology (Hons) - Universiti Putra Malaysia

MSc (Biochemistry) - Universiti Kebangsaan Malaysia

DPhil (Biomedical Science) - University of Ulster, UK

Genotoxicity

DNA damage and repair

Cytotoxicity and Genotoxicity of active compound from natural and chemical sources

Male infertility study

Genotoxicity study on electromagnetic irradiation

1.                  Analysis of the intergrity of sperm DNA using the Comet assay. (N10/2000 - UKM grant)

2.         Development of a diagnostic method for tumour staging in breast cancer patient using an immunological marker.  (N6/01-UKM grant).

3.                  The effect of microwave irradiation on rat’s lymphocytes.  (N8/00 – UKM grant)

4.                  The induction of genotoxicity effect by low-powered microwave irradiation

               (NN0032002X – UKM grant)

5.                  Evaluation of immunological parameters as a diagnostic tools for staging of breast

cancer patient.  (NN-003-2003 – UKM grant)

6.                  Evaluation on cytotoxicity potential of natural products in cosmetic ingredients

(IRPA 09-01-01-0021)

7.         Evaluation of genotoxicity potential of Malaysian natural products

(IRPA 03-03-04-05)

8.         Effect of local natural products such as goniothalamin on cellular proliferation

and apoptosis induction pertaining to coronary artery restanosis post-angioplasty.

(IRPA 06-02-02-0000-PR0014/06)

9.         Biomaterials for medical applications.

(IRPA 03-02-02-0035-PR0026/05-04)

10.       Evaluation and isolation of bioactive compounds from Garcinia atroviridis and

Solanom torvum. (IRPA 09-02-02-0053-EA149)

11.              Retrospective study of the involvement of diet in cancer

(NN-026-2004 – MAKNA (Malaysian National Cancer Council) grant)

1.         McKelvey-Martin, V.J., Ho, E.T.S., McKeown, S.R., Johnston, S.R., McCarthy,P.J., Rajab, N.F. & Downes, C.S.  (1998).  Emerging application of the Single Cell Gel Electrophoresis (Comet assay): I.  Management of invasive transitional cell human bladder carcinoma, and II.  Fluorescent In Situ Hybridisation Comets for the identification of damage and repaired DNA sequences in individual cells.  Mutagenesis 13(1). 1-8.

2.         McKenna, D.J.,  Rajab, N.F. , McKeown, S.R., McKerr, G. & .McKelvey-Martin, V.J.. (2003).  Use of the Comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines.  Radiation Research 159: 49-56.

3.         Rajab, N.F., McKenna, D.J., Diamond, J., Williamson, K., Hamilton, P.W. & McKelvey-Martin, V.J.  (2004).  Prediction of radiosensitivity in human bladder cell-lines using nuclear chromatin phenotype.  Cancer Research.  In press.

4.         N.F. Rajab, T.A. Yaakob, B.Y.Ong, M.Hamid, A.M.Ali, B.O. Annuar, S.H. Inayat-Hussain. (2004). DNA damage evaluation of hydroxyapatite on fibroblast cell L929 using the single cell gel electrophoresis assay.  Med. J. Malaysia, 59(Suppl B): 170-171.

5.         S.H. Inayat-Hussain,N.F. Rajab, H. Roslie, A.A. Hussin, A.M. Ali, B.O.Annuar. (2004).Cell Death Induced by Hydroxyapatite on L929 Fibroblast Cells.  Med. J. Malaysia, 59(Suppl B): 176-177.

Published Abstract

1.         Rajab, N.F. & McKelvey-Martin, V.J. (1999).  Preferential rejoining of g-radiation induced DNA strand breaks in the p53 domain of J82 bladder carcinoma cells.  Mutagenesis.  14(6): 649-650.

2.         Rajab, N.F., Hamilton, P.W., Diamond, J. & McKelvey-Martin, V.J.  (2000).  An assessment of radiosensitivity in bladder cancer cell lines.  Irish Journal of Medical Science.  4(Suppl. 4): 53.

3.         McKenna, D.J., Rajab, N.F. & McKelvey-Martin, V.J.. (2001).  A study of DNA damage and repair in the p53 gene region using the FISH-Comet assay.  Mutation Research.  483(Suppl. 1). S172.

4.         Rajab, N.F., F.A.Rahim, A.B.Osman, M.H. Helan, N.Shahab & S.H. Inayat-Hussain  (2001)  Safety assessment of Malaysian plant derived compounds as cosmetic ingredients.  Toxicology:164(1-3):170

5.         B.O.Annuar, M.H. Helme, A. Muhammad Hasib, A Noor Rabihah, Z. Sharifah Anum, T.A. Yaakob, S.H. Inayat-Hussain, N.F. Rajab, S.Saadiah, H.L.Hing, S.Sahidan.  (2004).  Preliminary Assessment of Hydroxyapatite and Tricalcium Phosphate: In Vitro and In Vivo studies.   Med. J. Malaysia, 59(Suppl B): 88

Proceedings/ Abstract

1.         Azimahtol, H.L.P., Lena, E.A. & Nor Fadilah, R.  (1993)  The antiproliferative effect of goniothalamin on human breast cancer cell line (MCF-7, MDA-MB-231 & T47-D).  Proceeding of the 18^th Malaysian Biochem Soc. Conference.  p177-181.

2.         Azimahtol Hawariah, L.P. & Nor Fadilah, R.  (1994).  Effect of styrylpyrone derivative on the mitogenic action of insulin in the proliferation of breast cancer cell line.  Proc. 19^th Malaysian Biochem Soc. Conf.  p58-60.

3.         Nor Fadilah, R. & Azimahtol Hawariah, L.P.  (1995).  Kesan pemulihan insulin dan estradiol ke atas tindakan terbitan stirilpiron dalam sel MCF-7 & MDA-MB-231.  Prosiding Seminar Hasil Penelitian.  Universiti Islam Riau, Indonesia. p110-112.

4.         Nor Fadilah, R. & Azimahtol Hawariah, L.P.  (1995).  Kesan terbitan stirilpiron ke atas tindakan mitogenik factor pengubah tumbesaran dalam sel barah mamari manusia.  Simposium Biologi Kebangsaan ke-5.  16-18 Mei 1995.  KRU Bangi.  p39.

5.         Nor Fadilah, R. & Azimahtol Hawariah, L.P.  (1995).  The recovery effect of insulin and estradiol on the action of styrylpyrone derivative in MCF-7 & MDA-MB-231 breast cancer cell lines.  Ann. Conf. Of the Malaysian Society for Biochem. & Mol. Biol.  Seremban, Negri Sembilan.  p35.

6.         Rajab, N.F., Toyoshima, M. & McKelvey-Martin, V.J.  (2000)  Use of alkaline comet assay for the detection of DNA damage induced by DNA-DNA crosslinking agent, Mitomycin C.  Proceedings on the 3^rd National Symposium in Health Sciences, PWTC, Kuala Lumpur. 3 : 367-373.

7.         Nihayah, M., Zirwatul Adilah, A. & N.F. Rajab  (2001)  Relationship between semen quality and DNA integrity of human spermatozoa.  Proceedings on the 1^st Asean Conference on Medical Sciences.  Kubang Kerian, Kelantan, Malaysia.

8.         Rajab N.F., Mat Isa, K.A., Kassim, I., Yusoff A.N. (2002).  The genotoxic potential of microwave (9.4GHz) on rat lymphocytes.  Proceedings of the 4^th National Symposium in Health Sciences, Kuala Lumpur.  p443-447.

9.         Inayat-Hussain, S.H., Rajab, N.F., Dewa, N., Ishak, M.H.A., Ali, A.M., Osman,A.B. & Farina, Y.  (2002).  Cytotoxicity of organotin derivatives in human promyelocytic leukemia HL-60 cells.  Proceeding of the 5^th UKM-ITB Joint Seminar on Chemistry, Malacca.  p99-102.

10.       Inayat-Hussain, S.H., Rajab, N.F., Mustafa, N.F., Ali, A.M., Annuar, B.O.& Farina, Y.  (2002).  Cytotoxicity and genotoxicity assessment of diorganotine derivatives in L929 fibroblast cells.  Proceeding of the 2^nd Asean Conference on Medical Sciences.  The Medical Journal of the Medical School, University of Sumatera Utara, Indonesia. p102.

11.       N.F. Rajab, Z.A. Hamid, H. Hassan, A.M. Ali, L.B. Din & S.H. Inayat-Hussain (2002)  Cytotoxicity and genotoxicity effect of styrylpyrone derivative goniothalamin in leukemic cells.  Proc.of the 18th Annual Seminar & Workshop of Malaysian Natural Products Society, Kota Kinabalu, Sabah.

12.       Rumiza A.R., Chang, Y.K., Nor Fadilah, R & Azimahtol Hawariah, L.P.,(2003).Safety assessment of goniothalamin using the toxicity, genotoxicity and mutagenicity study.  Malaysian Journal of Biochemistry & Molecular Biology. 8:90.

13.       Mohd Hasrol A. Ishak, Abdul M. Ali, Khalid Yusoff, Laily B. Din, Nor F. Rajab, Salmaan H. Inayat-Hussain. (2003).  Characterisation of goniothalamin induced cell death in Vascular smooth muscle cells.  Proc. of the 18^th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. HUKM, Kuala Lumpur. p162.

14.       Inayat-Hussain, SH, Chan, CL, Ishak, MHA, Rajab, NF, Din, LB, Ali, AM, Yusoff, K.  (2003).  Effects of tocotrienol on goniothalamin treated T-lymphoblastic leukemia cells.  Proc.  of the 5^th Global Network Of Molecular and Cell Biology (MCBN-UNESCO)/ COSTAM/Society for Free Radical Research (SFRR-Malaysia/ASEAN) Workshop.Kota Kinabalu, Sabah, Malaysia.  p121.

15.       Lee, CC, Poh, BK, Khairul, O, Sharifa, AA, Balkis, SB, Fatimah, SI, Fadilah, NR, Zahara, AM & Jamaludin, M.  (2003).  Assessment of DNA strand breakage by Alkaline COMET Assay and its relationship with plasma vitamin C in healthy men.  Proc.  of the 5^th Global Network Of Molecular and Cell Biology (MCBN-UNESCO)/ COSTAM/Society for Free Radical Research (SFRR-Malaysia/ASEAN) Workshop.Kota Kinabalu, Sabah, Malaysia. p133.

16.       Nihayah, M., Won, L.T., Zainul Rashid, M.R., Rajab, N.F., Nabishah, M. & Morat, P.B.  (2004).  Microdeletion of Y Chromosome in Azoospermic and Severe Oligospermic men.  Proceedings of the 5^th National Symposium in Health Sciences, Putrajaya, Malaysia.  P231-235.

17.       Lee, CC, Poh, BK, Osman, K, Balkis, S, Fadilah, NR , Siti Fatimah, I, Zahara, AM & Jamaludin, M. (2004).  Association of physical activity and DNA damage levels in police recruits and the effects of antioxidants supplementation.  Proceedings of the 5^th National Symposium in Health Sciences, Putrajaya, Malaysia.  P320-324.

18.              Rajab, N.F., Norbaya, E.M.E., Razak, A.A., Kassim, I. & Yusoff, A.N.  (2004).  The in vivo genotoxic evaluation on rat lymphocytes irradiated with microwave at 9.45GHz.  Proceedings of the 5^th National Symposium in Health Sciences, Putrajaya, Malaysia.  p450456-235.

19.       Nor Fadilah Rajab, Norhamizan Hashim, Tajul Anuar Yaakob, Engku Norbaya Engku Muda, Asmah Hamid, Jalifah Latip, Mohd Azman Abu Bakar & Paden Morat.  (2004).  Toxicological evaluation of Solanum torvum and Garcinia atroviridis fruit extracts in vitro.  Proceedings of 29^th Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology.  p98.