BSc.(Hon)Chem. Eng.(Leeds), PhD(QEC, London)

Professor

Fermentation technology, Industrial Biotechnology, Design of Waste Water Treatment Plant

1. Design of biological systems (single and multistage) for the production of 

   primary and secondary metabolites.

2. Evaluation (qualititive and quantitative) of fermentation process.

3. Development of high density biomass production systems.

4. Production of cellulase, CGTase, Itaconic acid, bioinsecticides, GLA,

    biotransformation of natural rubber

Title         : Continuous Hydrogenation of Palm Oil Using Supported Catalysts

            Duration   : 1986 - 1990

            Funding    : UKM. RM 55,000

            Member   : Professor Dr. Che Husna Azhari (Project Leader)

            Outcome  : A Postgraduate student

                              A Postgraduate Thesis

                              Two papers in journal and several papers in proceeding

                              A Final Report

2          Status       : Member

            Title          : Hydrodynamic Studies In Circulating Fluidised Bed Reactor

            Duration    : 1994

            Funding     :  Suruhanjaya Sains EC-Asean RM 450,000

            Members  : Prof. Pierre Guigon      

                              Prof. Khalil Shakourzadeh

                              Professor Dr. Che Husna Azhari (Project Leader)

                              Assoc. Prof. Dr. Siti Masrinda Tasirin

            Outcome  : A pilot plant -Circulating Fluidised Bed Reactor

                              A proceeding at the National Level                     

2                    Status      : Member

            Title         : Properties of Particle in Solid Flow

            Duration   : 1997- 1999

            Funding    : UKM RM 10,000

            Members  : Professor Dr. Che Husna Azhari (Project Leader)

                              Assoc. Prof. Dr. Siti Masrinda Tasirin

3                    Status       : Project Leader

            Title          : Biotransformation of Natural Rubber in Packed Bioreactor

                               System.

            Duration    : 1997- 1999

            Funding     : IRPA 01-04-0040 RM 70,000

            Members   : Dr. A. Ikram (RRI) (project leader)

                               Dr. Zainal Abidin (RRI)

                              Professor Dr. Che Husna Azhari

5          Status         : Member

            Title            : The Malays Technology

            Members     : Prof. Muhammad Haji Salleh SN dan Pengarah ATMA (project leader)

                                Prof. Dr.Wan Ramli Wan Daud

                                Prof. Dr. Che Husna Azhari

                                Assoc. Professor Dr. Wan Mohtar Wan Yusoff

                                Professor Dr. Kamaruddin Yusoff

                                Professor Dr. Hassan Basri

                                Assoc. Professor Dr. Yusoff Ali

                                Assoc. Prof.Dr. Shahidan Radiman

6          Status          : Project Leader

Title            : Preliminary Evaluation of Production of Bioinsecticides from local waste materials

            Duration       : 1987 -1991

            Funding        : RM 30,000 IFS E/1068 SWEDEN

            Member       : Prof Mohd Sanusi Jangi      

            Outcome      : Several undergraduate theses

                                Articles in proceeding                

7          Status           : Project Leader

            Title             : Utilization of Cells and Enzyme Production to change cellulosic        

                                 materials

            Duration       : 1988-1993

            Funding        : IRPA 4-07-03-008

            Members      : Prof. Dr.Abdul Jalil Abdul Kader  (Project Leader)     

                                  Prof. Dr.Othman Omar

                                  Assoc. Prof. Dr. Fauzi Daud

            Outcome       : A postgraduate student

                                  Several undergraduate theses

                                  Packed Bioreactor system for fermentation  processes

                                  Articles in proceeding/journals

8          Status            : Project Leader

            Title               : Continuous production of bioinsecticides

            Duration         : 1988 - 1993

            Funding          : IRPA 4-07-03-003

            Members        : Prof. Dr.Nor Muhammad Mahadi (project leader)

                                    Prof. Dr.Mohd Sanusi Jangi

           Outcome          : Several undergraduate theses

                                    A bioreactor system set–up for continuous production of  

                                    bioinsecticides  .

                                    Articles in proceeding/journal        

9         Status               : Project Leader

           Title                  : Production of Itaconic Acid for Biopolymers

          Duration            : 1991 - 1995

          Funding             : MPKSN RM 25,000 BP2 9370088

          Member            : Professor  Dr. Che Husna Azhari     

          Outcome           : A Postgraduate student

                                     Several undergraduate theses

                                    Articles in proceeding

10        Status              : Project Leader

Title                : The production of cyclodextrin glucosyl transferace (CGT ase) by bacteria.

Duration          : started Mac 2000

            Funding           : RM 72,000.00 KSTAS : IRPA 09-02-02-0118

            Member          : Dr. Aidil Abd. Hamid  UKM

                                    Dr. Rosli Md. Illias       UTM

                                    Dr. Noor Aini Abd. Rashid UTM

11        Status              : project leader

            Title                 : Biotransformation of natural rubber by actinomicete #4

            Funding            : KSTAS : IRPA 01-04-04-0040

            Fund                : RM 70,000.00

            Members         : Dr. A. Ikram    LGM

                                     Prof Dr. Che Husna Azhari   UKM

12        Status              : programme leader

            Title                 : Production of Microbial Polyunsaturated Fatty Acid

           Funding            : KSTAS : IRPA 09-02-02-001 (BTK/TD/001) Top-down RM8

            Fund                : RM 880,000 untuk 3 tahun (2001-2004)

            Members         : Dr. Aidil Abd. Hamid  UKM            secretariat

                                     Dr. Rosli Md. Illias      UTM            sub-project head

                                     Dr. Hirzun                  UPM            sub-project head

                                     Dr. Subari                   MARDI        sub-project head

1         Ismail B. Ahmad, Zubaidah A. Hassan Goh Toh Seng, Shanmugam K. Murthy,Siti Romlah Yahya, Nurina Anuar,  Wan Mohtar W. Y. & Laily B. Din (1989).  Biologi Chaetomium sp dan Kesan Perencatan Terhadap Pertumbuhan Beberapa Bakteria.  Sains Malaysiana 18(3): 55-64.

2         Wan Mohtar Wan Yusoff & Ravindran Thayan (1990).  Cellulose degradation in a packed reactor system using mixed culture fermentations.  Journal of the Singapore National Academy of Science, Vol. 18 & 19, 13-16

3         Wan Mohtar Wan Yusoff. &  Ravindran (1991).  Synergism of  b-glucosidase and cellulose in mixed culture fermentations.  Malays.  Appl. Biol. Vol. 20(2):215-222.

4         Jalil Kader, Zainal Abdin Mohd Yusoff, Othman  Omar, Wan Mohtar  Wan Yusoff & Fauzi Daud (1992).  Pemencilan mikroorganisma selulolisis daripada enapcemar kelapa sawit.  Sains Malaysiana 21(5), 75-85.

5         Wan Mohtar Wan Yusoff., Abd. Jalil Abd. Kader, Sasidharan Velayutham, Othman Omar (1992).  Effects of temperature on continuous cellulolysis by Aspergillus terreus SUK-1 in a packed reactor system.  Jurnal Sains Malaysiana (Sains Hayat) 21(3), 41-50.

6         Che Husna Azhari, Sufian Ali & Wan Mohtar Wan Yusoff (1992).  Penghidrogenan selanjar minyak olein sawit dengan mangkin platinum tersokong.  Jurnal kejuruteraan 4:61-70.

7         Wan Mohtar Wan Yusoff. & M.J. Bazin (1994).  Simultaneous production of cellulase and reducing sugar in a multistage packed reactor system.  ASEAN J. Sci. Technol. Develop. 11(2):107-116.

8         Wan Mohtar Wan Yusoff., Che Husna Azhari & D. Lonchamp. (1994). Separation  by selective adsorption : Preparative Liquid Chromatography.  Journal of Industrial Technology, 4(1):79-86.

9         Wan Mohtar Wan Yusoff., K.M. Shanmugam, & I.B. Ahmad (1995).  Cultivation of Chaetomium trilaterale Chivers for antibiotic production in submerged culture.  Malays.  Appl. Biol. 24(2):95-100.

10     Wan Mohtar Wan Yusoff. & S. Suresh (1996).  The effect of aeration rate on itaconic acid production by entrapped Aspergillus Terreus SUK-1 in a packed bioreactor system.  Malays. Appl. Biol. 25(1):75-80.

11     Wan Mohtar Wan Yusoff., Abd. Jalil Abd. Kader & Othman Omar (1996). Effect of reactor operation, substrates  and medium flowrate in the continuous production of cellulase enzyme in a packed reactor.  Malays.  Appl. Biol. 25(2): 81-88.

12     Wan Mohtar Wan Yusoff, Othman O. , J.Kader, Suresh.S dan Shree Mano.J 1997. Effects of sodium chloride on cellulase production by Aspergillus terreus SUK – 1 Malays. Appl. Biol 26(1): 1-5

13     Kader. Jalil, Getha Krishnasamy, Wan Mohtar Wan Yusoff and Othman Omar.(1999).

Hydrolysis of empty fruit bunch of oil palm using cellulolytic enzymes from Aspergillus terreus IMI 28243.

J. Microbiol. Biotechnol. 9 (4), 514-517.

14     Che Husna Azhari , Siti Masrinda Tasirin, Mulfi Hazwi & Wan Mohtar Wan Yusoff (2000)

Studies on axial solid flow structures in CFB reactors.

Jurutera,  IEM, MALAYSIA No. 10 Bil. 2000 : 49-56

15     Wan Mohtar Wan Yusoff , Muhannad Illayan Massadeh & Jalil Kader. (2000)

Solid Substrate and submerged culture fermentation of sugar cane bagasse for the production of cellulase and reducing sugar by a local isolate, Aspergillus terreus IMI 28243.

J. Microbiol. Biotechnol. 10 (5), 770-775

16     Wan Mohtar Wan Yusoff, Muhannad I. Massadeh, Othman Omar and Jalil Kader. (2000)  Sugar cane bagasse degradation by mixed culture of T. reesei and A. terreus in solid substrate fermentation. Pakistan Journal of Biological Sciences 3 (10) : 1758-1761.

17     Wan Mohtar M.Y, Ho Y.H and Pang W.K. (2000). The effect of cellulose in the production of itaconic acid by Aspergillus terreus IMI 28243. Malays. Appl. Biol,29 (1&2): 149-151

18     Wan Mohtar Wan Yusoff, Pang Wey Kit , Osman Hassan & Suresh Suppiah. (2001) Influence of Cobalt, Nickel and Zinc on itaconic acid production by a local isolate Aspergillus terreus IMI 28243. Pakistan Journal of Biological Sciences 4(1) : 107-109

19     Siti Maslinda Tasirin, Wan Mohtar W. Y, Mulfi Hazwi Mohd Dien & Che Husna Azhari (2001) Influence of Particle Size on the axial flow profile in a rectangular CFB riser. 6^th World Congress of Chemical Engineering. Melbourne2001. P3-205. 1-9 Inst of Chem. Eng. Aust.

20     A. Hamid, W.M.W. Yusoff, R.M. Illias & K. Nadarajah (2001).  Pengasingan strain baru kulat dari tanah di Malaysia untuk penghasilan asid  ?– linolenik (GLA).  Jurnal Teknologi, 34 (C) Jun 2001 : 1-8

21     M.I. Massadeh, W.Mohtar W. Yusoff, O. Omar and J. Kader (2001). Synergism of  cellulase enzymes in mixed culture solid substrate fermentation.  Biotechnology Letters .  23: 1771-1774

22   Wan Mohtar Wan Yusoff, Mohd Mazmira Mohd Masri, Bhavani, U. and

Rusni Maruan (2001).  Growth and Sporulation of Bacillus thuringiensis

subsp. aizawai SN2 in a two-stage continuous culture.  Journal of Industrial

Technology vol. 10 No.2 ( in press)

23    W.Y.Wan Mohtar, W.G.Loh, and H. Osman (2001). Effect of NaCl in agar medium, growth medium and production medium in the production of itaconic acid by Aspergillus terreus IMI 282743. Malays. Appl. Biol. (June & December 2001) 30(1&2) : 99-103

24    Che Husna Azhari, Aulia Saad, Wan Mohtar Wan Yusoff and A. Ikram (2002). Biodegradation of natural rubber by Actinomycete No. 4 in a continuous culture system. Pakistan journal of Biological Sciences 5(3): 329-331.

25    Rosli Md. Illias, Tien Siew Fen, Nor Aini Abdul Rashid, Wan Mohtar Wan Yusoff, Aidil Abd. Hamid, Osman Hassan & Kamaruzzaman Kamaruddin (2002). Cyclodextrin Glucanotransferase producing alkalophilic Bacillus species.G1: It’s cultural conditions and partial characterisation of the enzyme. Pakistan journal of Biological Sciences 5(6): 688-692.

26  Mohd Sahaid Kalil, Pang Wey Kit, Wan Mohtar Wan Yusoff, Yoshino Sadazo and Rakmi Abdul Rahman (2003). Direct Fermentation of Palm Oil Mill Effluent to Acetone-botanol-ethanol by solvent producing Clostridia. Pakistan Journal of Biological Sciences 6 (14): 1273-1275. Asian Network for Scientific Information

27  Wan Mohtar Wan Yusoff, Hanan Moawia Ibrahim, Aidil Abdul Hamid, Rosli Md. Illias, Osman Hassan and Othman Omar (2002). A potential new isolate for b-Cyclodextrin Glucanotransferase production. Malaysian Journal of Biochemistry and Molecular Biology. Vol 7: 13-17

28  Mohd. Sahaid Kalil, Muhammad Zaki, Wan Mohtar Wan Yusoff & Mohammad Ramlan Mohd Salleh (2003). Sebatian metoksiaromatik sebagai substrat pertumbuhan dan pengaruh enzim demetilase dalam Acetobacterium Woodii DSM1030. Jurnal Teknologi no.38 (C), Jun 2003: 61-68

29  Wan Mohtar,W.Y. and Mohd Mazmira, M.M. (2003). Medium formulation for improvement of growth and sporulation of Bacillus thuringiensis Subsp Kurstaki using a two-stage continuous culture. Malays. Appl. Biol.(jun 2003) 32(1): 61-67

30  Rosli Md. Illias, Tien Siew Fen, Roshanida A Rahman, Noor Aini Abdul Rashid, Wan Mohtar Wan Yusoff, Aidil Abd. Hamid, Osman Hassan & Kamaruzzaman Kamaruddin (2003). Application of factorial design to study the effects of temperature, initial pH and agitation on the production of Cyclodextrin Glucanotransferase from alkalophilic Bacillus sp G1. Science Asia 29:135-140

31  Hanan Moawia Ibrahim, Wan Mohtar Wan Yusoff, Aidil Abdul Hamid, Rosli Md. Illias and Othman Omar (2003). Optimisation of the process conditions for Cyclodextrin Glucanotransferase production using response surface methodology. Asian J. of Microbial. Biotech. Env. Sc. 3: 297-300

32  Wan Mohtar Wan Yusoff, Muhannad I Massadeh, Jalil Kader, Fauzi and Othman Omar (2003). Comparison of cellulolytic enzymes production by single-stage solid fermentation (SSF) and submerged culture fermentation(SCF) and the combination of SSF and SCF fermentation systems. Jurnal Biosains Vol. 14 No. 2, 7-17

33  Pang Wey Kit, Mohd Sahaid Kalil, Osman Hassan & Wan Mohtar Wan Yusoff (2004). Penghasilan Aseton-Butanol-Etanol dan gas hydrogen daripada efluen kilang kelapa sawit secara fermentasi anaerobic dengan Clostridium acetobutylicum NCIMB 13357. Sains Malaysiana 33(1): 73-81

34  Hanan Moawia Ibrahim, Wan Mohtar Wan Yusoff, Aidil Abdul Hamid, Rosli Md. Illias, Osman Hassan, Othman Omar (2005). Optimization of medium for the production of b-cyclodextrin glucanotransferase using central composite design (CCD). Process Biochemistry 40 (2005) 753-758.

35 Aidil, A.H., Rosli, M.I. and Wan Mohtar, W. Y. (2005). The effect of carbon and nitrogen ratios and temperature on lipid and gamma-linolenic acid (GLA) yield in four fungal isolates. Malaysian Applied Boilogy 34(1): 15-19

36  Muhammad Zaki, Che Husna Azhari, Mohd Sahaid Kalil and Wan Mohtar Wan Yusoff (2005). Production of Novel Material through Biotransformation of Natural Rubber. Journal of Applied Technology (jurnal teknologi terpakai). Vol.2 No.2 (91-98)

 37 K.Nadarajah, Paul, D.C., J. Kader and W. M. Wan Yusoff (2005). The effects of soluble carbon sources on the production of chitosan by a new isolate of Rhizopus oligosporus. Malaysian Applied Biology 33(2):27-34

       38 Siti Aminah, S., Aidil, A. H. and Wan Mohtar, W. Y. (2006). Medium   

           Optimization for the production of lipidless biomass by Cunninghamalla sp.

           2A1 using response surface methodology. Malaysian Journal of Microbiology,  

           Vol 2(1), 40-45

 39 Nadarajah, K., Lau, B.Y.C., Othman, O., Hasidah, M.S. and Wan Mohtar,

     W.Y. (2006). Characterization of Chitin Deacetylase from fungus Absidia

     Butleri   dr. Malays. Appl. Biol. 35(2): 59-65

       40 Nur-Ainee Hayeeyusoh, Aidil Abdul Hamid and Wan Mohtar Wan    

           Yusoff (2007). A Simple Technique to Enhance the Productivity of delta-

           endotoxin in Batch  Culture. NU Science Journal; 4(1): 18-24