CURRICULUM VITAE
  • Name : SALMAAN HUSSAIN BIN INAYAT HUSSAIN
  • Qualifications :

         B Sc (Hons)  Pharmacology (2nd upper) 1991,UKM 

     

      PhD (Biochemical Toxicology), 1997, Medical Research Council Toxicology Unit, Leicester &  University Of Leicester, England

      Eurotox Registered Toxicologist (2005-2010)

     

     
  • Specialisation :

    Biochemical Toxicology and Cancer Pharmacology

     
  • Areas of Research :

    Molecular Mechanisms of benzene induced apoptosis

    Anti-cancer effects of styryllactones and quinones

    Apoptosis in vascular smooth muscle cells-model for restenosis post-angioplasty
  • Current Projects and Grants :

     

    INTERNATIONAL

    Molecular and Biochemical Studies on DT-diaphorase

    University of Colorado

    (March-December 2004)

    Completed

    (Leading the  Apoptosis Research Section)

    NIH (NCI) RO1 CA51210 (12-16)

     NQO1, oxidative stress and proteasomal inhibition

    University of Colorado

    (March-December 2004)

    In Progress

    (Leading the Apoptosis Research Section)

    NIH (NINDS) RO1 NS44613 (01-05

    Japan Society for Promotion of Science (JSPS) – Malaysian Vice- Chancellors’ Council (VCC) Ten Year Research Programme Environmental Science, Ethics and Engineering: Towards Zero

    Discharge Society: 2000-2009

    (Group: Environmental Toxic Evaluation & Management & Risk Assessment)

    Malaysia

    UKM,USM,KUSTEM and UM

    Japan

    Kyoto University and Okayama University

    (2000-2009)

    In Progress

     

    JSPS-VCC

    Assessment of environmental genotoxins in industrial wastewater and river

    Universiti Kebangsaan Malaysia

    (2005-2006)

    In Progress (Project Leader)

    Kurita Water and Environment Foundation 

    (NN-017-2005)

    Analysis of the molecular mechanisms controlling the induction of apoptosis by natural styryllactones including goniothalamin

    Universiti Kebangsaan Malaysia, Keele University (UK) and King’s College London

    (2005-2008)

    In Progress (Project Leader)

    The  Wellcome Trust

    (NN-018-2005)

     

    NATIONAL

    Molecular Mechanism of Goniothalamin induced apoptosis on vascular smooth muscle cells as a model for restenosis postangioplasty

    Universiti Kebangsaan Malaysia

    (2005-2007)

    In Progress (Project Leader)

    SAGA-Akademi Sains Malaysia (NN-001-2005)

     

     

     

     
  • Selected Publications :

    Inayat-Hussain, S.H.*, Winski, SL, Ross, D (2001) Differential involvement of caspases in hydroquinone-induced apoptosis in human leukemic HL-60 and Jurkat cells. Toxicology and Applied Pharmacology 175, 95-103.

     

    Inayat-Hussain SH*, Annuar BO, Din LB and Taniguchi N (2002) Altholactone, A Novel Styryl-Lactone Induces Apoptosis Via Oxidative Stress In Human HL-60 Leukemia Cells. Toxicology Letters 131, 153-159.

     

    Inayat-Hussain, SH,*  Osman, AB, Din, LB,  Ali, AM and Ross, D (2003) Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells. Toxicology In Vitro  17, 433-439.

     

    Inayat-Hussain,S.H., N.F. Rajab, H. Roslie, A.A. Hussin, A.M. Ali, B.O.Annuar. 2004.Cell Death Induced by Hydroxyapatite on L929 Fibroblast Cells. Med. J. Malaysia, 59(Suppl B): 176-177.

     

    Inayat-Hussain, S.H*. and Thomas, N (2004) Recent Advances In The Discovery And Development Of Lactones And Stilbenes In Anticancer Therapy. Expert Opinion on Therapeutic Patents  14 (6):819-835

     

     

    Inayat-Hussain, SH* and Ross, D (2005) Differential involvement of the mitochondrial/caspase-9 dependent apoptotic pathway in hydroquinone treated HL-60 and Jurkat leukemia cells. Chem Res Toxicol 18(3):420-7.

     

    Dehn, DL, Inayat-Hussain, SH & Ross D* (2005) RH1 induces cellular damage in an NQO1-dependent manner:Relationship between DNA cross-linking, cell cycle perturbation and apoptosis. J Pharmacol Exp Ther. 313(2):771-9.

     

    Chan,   K.M., Rajab, N.F., Ishak, M.H.A.,  Ali, A.M., Yusoff, K., Din, L.B. & Inayat-Hussain, S.H.*  (2006) Goniothalamin induces apoptosis in vascular smooth muscle cells. Chemico-Biological Interactions 159(2):129-40

            Journal impact factor: 1.8

     

     

              Zafar, KS, Inayat-Hussain, SH, Siegel, D, Bao, A, Shieh, S & Ross, D * (2006) Overexpression of NQO1 protects human SK-N-MC  neuroblastoma cells against dopamine-induced cell death. Toxicology Letters 166(3); 261-267

            Journal impact factor: 2.78 

     

                    

     

                   Eeling, S, Rajab, NF, Annuar, BO, Sudesh, K, Inayat-Hussain, SH* (2007) In vitro biocompatibility Evaluation Of Poly(3-Hydroxybutyrate-Co- 4-Hydroxybutyrate)  [P(3HB-Co-4hb) Copolymer In Fibroblast Cells. Journal of Biomedical Materials Research A 81(2);317-325

            Journal impact factor: 2.49

     

                    Inayat-Hussain SH *., Lubis, SH, Ghazali, R, Sakian, NI., Ghazali, AR, Ali, NS, Sersi, EM, Lee, MT, Zainab, AM, Hashim, S, Ghazali, MS, Saidin, MN, Ab Rahman, AR, Rafaai, MJM, Omar, S, Rapiai, R, Othman, R, Chan, TL, Johari, A, Soon, WH,  (2007) Is beta-glucuronidase a novel biomarker for anticholinesterase poisoning? A Malaysian experience. Toxicology and Applied Pharmacology 219 (2-3); 210-216

            Journal impact factor: 4.722

     

            Zafar, KS, Inayat-Hussain, SH & Ross, D* (2007) A comparative study    of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells  by dopamine and MG132. Journal of Neurochemistry  102(3):913-21      Journal impact factor: 4.26

     
  • Contact Information :
    - Address

      FACULTY OF HEALTH SCIENCES
      Jalan Raja Muda Abdul Aziz
      50300 Kuala Lumpur
      Malaysia
    - Phone Number
      40405627
    - Fax Number
      26929032
    - E-mail